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KMID : 1044820210510050342
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Journal of Periodontal & Implant Science
2021 Volume.51 No. 5 p.342 ~ p.351
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Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study
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Blanco Carlota
Linares Antonio
Dopico Jose
Pico Alex
Sobrino Tomas
Leira Yago
Blanco Juan
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Abstract
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Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis.
Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed.
Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×103/μL; 95% CI, 1.6, 4.0×103/μL; P<0.001) and IL-10 (estimated adjusted mean difference, ?10.4 pg/mL; 95% CI, ?15.8, ?5.0 pg/mL; P<0.001). The peri-implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001).
Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low-grade systemic inflammation and dyslipidemia.
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KEYWORD
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Cardiovascular diseases, Dyslipidemias, Inflammation, Leukocytes, Peri-implantitis
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